1-Hydroxybenzotriazole hydrate - 157260-25G

1-Hydroxybenzotriazole hydrate - 157260-25G

wetted with not less than 14 wt. % water, 98% dry basis

Synonym(s):
HOBt Hydrate
Empirical Formula (Hill Notation):
C6H5N3O · xH2O

PROPERTIES
Quality Level
200

Assay
98% dry basis

form
solid

quality
synthesis grade

reaction suitability
reaction type: Addition Reactions

mp
155-158 °C (lit.)

application(s)
peptide synthesis

SMILES string
[H]O[H].On1nnc2ccccc12

InChI
1S/C6H5N3O.H2O/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H2

InChI key
PJUPKRYGDFTMTM-UHFFFAOYSA-N

DESCRIPTION
Application
1-Hydroxybenzotriazole hydrate can be used as a reagent:
To synthesize β-peptides via microwave-assisted amino acid coupling.
In the spot synthesis of glycopeptides.
It can also be used as a deprotection agent for the removal of Fmoc (9-fluorenylmethoxycarbonyl) protecting group.

SAFETY INFORMATION
Pictograms
FlameExclamation mark
GHS02,GHS07
Signal Word
Danger

Hazard Statements
H207 - H319 - H412
Precautionary Statements
P210 - P212 - P230 - P233 - P280 - P370 + P380 + P375 - P501
Hazard Classifications
Aquatic Chronic 3 - Desen. Expl. 2 - Eye Irrit. 2

Supplementary Hazards
EUH044
Storage Class Code
4.1A - Other explosive hazardous materials

WGK
WGK 1

Flash Point(F)
314.6 °F

Flash Point(C)
157 °C