Jasplakinolide -50ug - 11705

Jasplakinolide is a natural macrocyclic peptide first isolated from a marine sponge. It potently inhibits the proliferation of PC3 prostate carcinoma cells (IC₅₀ = 35 nM) by binding F-actin (KD = 15 nM).¹ This binding of jasplakinolide to actin, which is competitive with phalloidin, stabilizes actin filaments in vitro but disrupts actin filaments and induces irregular polymerization of monomeric actin in vivo.^1,2 This compound is used to investigate the role of actin in diverse cellular roles, such as motility, transport, and development.^3,4

WARNING This product is not for human or veterinary use.